Archive for July 22nd, 2010
July 22nd, 2010 | 
Author: Selective inhibitors of cyclooxygenase type 2 do not exert negative effects on cartilage and some of them like Celebrex (Celecoxib) contributes to increase of glycosaminoglycans synthesis as well possess a positive influence on the course of the knee joints osteoasthrosis. 2-years placebo controlled trial proved a high effectiveness of Celebrex in management of pain, stiffness and inflammation. The effects of Celebrex are comparable with glucosamine, chondroitin sulfate or their combination. Since cyclooxygenase is involved in the activation of osteoclasts, selective inhibitors of cyclooxygenase type 2 belongs to a first line treatment of patients with osteoporosis or with a risk factor for osteoporosis development.
In spite of its advantages, Celebrex may have some negative effects. Like other NSAID medication, Celebrex could increase the chance of having a heart attack or stroke, possibly resulting in death. The risk is greater if you have heart disease or use NSAIDs for a long time. It’s important to discuss the risks and benefits of using Celebrex with your doctor and to use the lowest effective dose for the shortest amount of time possible.
Although Celebrex is easy on the stomach, it still poses some degree of risk-especially if you’ve had a stomach ulcer or gastrointestinal bleeding in the past. All NSAIDs, including Celebrex, can cause serious-and even life-threatening-ulcers and bleeding in the stomach and intestines. These side effects can happen without symptoms and may occur at any time during treatment. If you’ve ever had ulcers or stomach bleeding, make sure the doctor is aware of it. And be sure to alert the doctor if you develop any digestive problems or notice a change in your bowel movement (such as blood in the stool or black, sticky stools).
Full Article: Celebrex - a drug of choice in the treatment of osteoarthritis
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